Structure of biological macromolecules that are targets of drugs. Techniques to accelerate directed drug discovery. Protein structure/interactions. Popular target classes. Computational tools for visualizing/analyzing protein-ligand and protein-protein interactions. Structural characterization at a level sufficient to underpin critical data evaluation. Biophysical techniques to assess weak ligand binding and suitable for fragment-based lead discovery.prereq: 5710 or 8002 or CHEM 5412 or structural biochemistry or instr consent