This course will provide an in-depth review of pathophysiological principles at the mechanistic and clinical levels across the lifespan. Basic science principles will be reviewed in conjunction with clinical assessments and diagnoses, to effectively inform therapeutic decision making. Deviations from normal physiological processes will be a focus across all systems. Clinical case studies will be used to enhance understanding of key scientific principles at the local and systemic levels. Students will be able to apply knowledge gained in clinical settings on common diseases as well as rare and esoteric disorders using current research, theory, and relevant case studies.