This course introduces students to a variety of concepts, tools, and techniques that are relevant to the rigorous design and analysis ofcomplex biomedical studies. Topics include ANOVA, sample-size calculations, multiple testing, missing data, prediction, diagnostictesting, smoothing, variable selection, the bootstrap, and nonparametric tests. R software will be used. Biostatistics students arestrongly encouraged to typeset their work using LaTeX or in R markdown.prereq: [7405, [STAT 5102 or concurrent registration is required (or allowed) in STAT 5102], biostatistics major] or instr consent